Sachiko Kajigaya Selected Research

Bone Marrow Failure Disorders

11/2022	Oligoclonal T-cell expansion in a patient with bone marrow failure after CD19 CAR-T therapy for Richter-transformed DLBCL.
1/2019	Interleukin-18 plays a dispensable role in murine and likely also human bone marrow failure.
1/2018	Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes.
1/2018	PD-1 deficiency augments bone marrow failure in a minor-histocompatibility antigen mismatch lymphocyte infusion model.
12/2017	Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells.
1/2016	PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function.
6/2014	A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome.
9/2009	Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.
1/2006	Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles.
4/2003	Mitochondrial DNA mutations in patients with myelodysplastic syndromes.

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Sachiko Kajigaya Research Topics

Disease

14	Aplastic Anemia (Anemia, Hypoplastic) 01/2022 - 04/2005
10	Bone Marrow Failure Disorders 11/2022 - 04/2003
10	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 04/2003
5	Neoplasms (Cancer) 01/2018 - 02/2006
4	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 06/2004
3	monosomy Chromosome 7 12/2021 - 12/2004
2	Fibrosis (Cirrhosis) 12/2020 - 01/2018
2	Cytopenia 12/2020 - 01/2016
2	Liver Diseases (Liver Disease) 01/2019 - 01/2018
2	Aneuploidy (Aneuploid) 01/2019 - 12/2017
2	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2014 - 01/2006
2	Leukemia 01/2007 - 06/2005
1	Large Granular Lymphocytic Leukemia 11/2022
1	Hematologic Diseases (Blood Diseases) 01/2022
1	deficiency of adenosine deaminase 2 01/2021
1	Thrombocytopenia (Thrombopenia) 12/2020
1	GATA2 Deficiency 01/2020
1	Inflammation (Inflammations) 01/2019
1	Autoimmune Diseases (Autoimmune Disease) 01/2019
1	Non-alcoholic Fatty Liver Disease 01/2018
1	Anemia 01/2018
1	Alcoholic Fatty Liver 01/2018
1	Immune System Diseases (Immune Disorders) 12/2015
1	Infections 10/2010
1	Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita) 09/2009
1	Kidney Neoplasms (Kidney Cancer) 03/2008
1	Congenital Bone Marrow Failure Syndromes 08/2007
1	Shwachman-Diamond Syndrome 08/2007
1	Autosomal Recessive 3 Severe Congenital Neutropenia 09/2006
1	Carcinogenesis 05/2006
1	Lymphoid Leukemia 06/2005
1	Myeloid Leukemia (Leukemia, Myelocytic) 06/2005
1	Residual Neoplasm 06/2004
1	Genomic Instability 01/2004
1	Sideroblastic Anemia 04/2003
1	Fanconi Anemia (Fanconi's Anemia) 01/2002
1	Hypersensitivity (Allergy) 01/2002

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2002
5	RNA (Ribonucleic Acid)IBA 11/2022 - 04/2005
5	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2019 - 04/2005
5	MicroRNAs (MicroRNA)IBA 01/2018 - 02/2006
4	Mitochondrial DNA (mtDNA)IBA 01/2007 - 04/2003
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2017
3	AntigensIBA 01/2018 - 06/2005
2	telomerase RNA (bTR)IBA 06/2014 - 04/2005
1	Cell-Free Nucleic AcidsIBA 01/2022
1	HLA-B Antigens (HLA-B)IBA 12/2021
1	HLA-A Antigens (HLA-A)IBA 12/2021
1	eltrombopag FDA Link 12/2020
1	Thrombopoietin ReceptorsIBA 12/2020
1	Thrombopoietin (c-mpl Ligand)IBA 12/2020
1	Reticulin (Reticular Fiber)IBA 12/2020
1	Interleukin-18 (Interleukin 18)IBA 01/2019
1	Calgranulin BIBA 01/2019
1	AlarminsIBA 01/2019
1	Long Noncoding RNAIBA 01/2019
1	Blood Proteins (Serum Proteins)IBA 12/2018
1	Minor Histocompatibility AntigensIBA 01/2018
1	Small Cytoplasmic RNAIBA 12/2017
1	Methotrexate (Mexate)FDA LinkGeneric 01/2016
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2016
1	gamma-AIBA 01/2016
1	Transcription Factors (Transcription Factor)IBA 01/2016
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2016
1	Histocompatibility Antigens (Histocompatibility Antigen)IBA 01/2016
1	2,2-bis(4-glycidyloxyphenyl)propaneIBA 01/2016
1	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 01/2014
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2014
1	erucylphosphocholineIBA 10/2010
1	AndrogensIBA 09/2009
1	Interleukin-23 (Interleukin 23)IBA 07/2009
1	Hepatitis B e AntigensIBA 03/2008
1	NFATC Transcription FactorsIBA 09/2007
1	Messenger RNA (mRNA)IBA 09/2007
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 09/2006
1	Protein Isoforms (Isoforms)IBA 09/2006
1	NucleotidesIBA 02/2006
1	Interferon-gamma (Interferon, gamma)IBA 01/2006
1	Cathepsin GIBA 06/2005
1	CD40 Ligand (CD40L)IBA 06/2005
1	Leukocyte Elastase (Neutrophil Elastase)IBA 06/2005
1	Myeloblastin (Proteinase 3)IBA 06/2005
1	MutagensIBA 06/2004
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2004
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 04/2003
1	DNA (Deoxyribonucleic Acid)IBA 01/2002
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/2002
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 01/2002

Therapy/Procedure

6	Therapeutics 11/2022 - 12/2004
3	Stem Cell Transplantation 01/2016 - 06/2005
1	Immunotherapy 01/2018
1	Hematopoietic Stem Cell Transplantation 03/2008
1	Drug Therapy (Chemotherapy) 01/2007